For an oocyte to generally be ready for fertilization and expansion into an embryo, the ideal set of genes must be turned on. Namekawa suspected this pre-programming of the oocyte genome transpires in various levels — the primary 1 setting up around the time a woman is born. He thought that chromatin remodeling proteins did Significantly of the work, by shifting spools around.
“Our target is to understand feminine reproductive aging, and why fertility speedily declines starting inside the mid-30s,” says Satoshi Namekawa, a professor of Microbiology and Molecular Genetics, in whose lab Munakata functions.
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Using the GCRLE grant, Munakata and Namekawa will search much more carefully at how oocytes are genomically primed and saved for later use. They'll look into the position of a chromatin remodeler in oocyte survival and fertility.
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“We don’t know how these cells are managed for decades,” suggests Namekawa. “We need to know The trick of the mechanism.
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